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  • The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight loss in addition to a reduced-calorie diet and physical activity. Using two separate drugs to shed weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you need to err to the side of caution and allow the FDA do its job and demand some study be done so that the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on their medications. Researchers discovered that participants taking this drug for a year, lost weight within a month and have kept the load off through the entire 56 weeks of the study. Contrave can be a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which might make them more effective and safer. Combo-pilling is the newest fad or also the newest to come under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that at the time of right now there aren't any long term prescription diet pills that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug also can raise blood pressure level and heartbeat, and really should not be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high hypertension, in addition to by you are not heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients on the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation. "This may be the first drug I'm mindful of that targets both appetite and reward centres in the brain," he was quoted saying.